Topical application of Mitomycin C for the treatment and prevention of scar formation in the areas of head and neck

Clinical Investigation, Children's Hospital, Boston Massachusetts

Scar formation is a response of the healing process.  After surgery the amount of scarring which occurs could lead to poor outcome in certain procedures.  Prevention and treatment of scar formation have been difficult in certain areas of the head and neck.  Conditions such as repair of choanal atresia, laser excision of subglottic stenosis may not be effective in about 50 - 70% of the cases because of the scarring response.  Scarring may necessitate further surgery.  The purpose of this research is to study whether the application of Mitomycin C at the surgical site will prevent scar formation.

Mitomycin has been used in a number of procedures to prevent scar formation in areas of ophthalmology (eye surgery).  Mitomycin C is an antibiotic used in chemotherapy for certain cancer treatments.  It is thought to reduce scar formation which is the basis for poor surgical results leading to airway (nose, larynx, trachea, etc.) obstruction.

At the end of the procedure, a small amount of Mitomycin C is applied topically to the surgical site that has a high chance of scar formation, for 2 - 4 minutes. 

We do not know whether the use of Mitomycin C will reduce scar formation.  However, Mitomycin C is known to reduce collagen synthesis, which is the basis for scar formation.  Therefore, we hope it will reduce scar formation and reduce the need for more surgery.